Formin Homology 2 Domain Containing 3 ( FHOD 3 ) Variants Associated with Hypertrophic Cardiomyopathy Running title : Wooten et al . ; FHOD 3 Variants Associated with HCM
نویسندگان
چکیده
Molecular Cardiology Rsrch Inst Ctr for Translational Genomics, Dept of Medicine, Cardiology Division, Tufts Medical Ctr, Boston, MA;Dept of Medicine, Division of Cardiovascular Diseases, Dept of Molecular Pharmacology & Experimental Therapeutics, Dept of Pediatric & Adolescent Medicine/Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN;Dept of Medicine, Duke University Medical Center, Durham, NC *contributed equally as first authors / **senior authors
منابع مشابه
Assigning a causal role to genetic variants in hypertrophic cardiomyopathy.
Formin Homology 2 Domain Containing 3 Variants Associated With Hypertrophic Cardiomyopathy Eric C. Wooten, PhD; Virginia B. Hebl, MD; Matthew J. Wolf, MD, PhD; Sarah R. Greytak, PhD; Nicole M. Orr, MD; Isabelle Draper, PhD; Jenna E. Calvino, BA; Navin K. Kapur, MD; Martin S. Maron, MD; Iftikhar J. Kullo, MD; Steve R. Ommen, MD; J. Martijn Bos, MD, PhD; Michael J. Ackerman, MD, PhD; Gordon S. Hu...
متن کاملFormin Homology 2 Domain Containing 3 (FHOD3) Variants Associated with Hypertrophic Cardiomyopathy
Molecular Cardiology Rsrch Inst Ctr for Translational Genomics, Dept of Medicine, Cardiology Division, Tufts Medical Ctr, Boston, MA;Dept of Medicine, Division of Cardiovascular Diseases, Dept of Molecular Pharmacology & Experimental Therapeutics, Dept of Pediatric & Adolescent Medicine/Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN;Dept of Medicine, Duke University Medical Center...
متن کاملFormin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy.
BACKGROUND Incomplete penetrance and variable expression of hypertrophic cardiomyopathy (HCM) is well appreciated. Common genetic polymorphisms variants that may affect HCM penetrance and expression have been predicted but are not well established. METHODS AND RESULTS We performed a case-control genomewide association study to identify common HCM-associated genetic polymorphisms and then aske...
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Formins are a conserved group of proteins that nucleate and processively elongate actin filaments. Among them, the formin homology domain-containing protein (FHOD) family of formins contributes to contractility of striated muscle and cell motility in several contexts. However, the mechanisms by which they carry out these functions remain poorly understood. Unlike other formins, mammalian FHOD1 ...
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